Histological Profile of Liver of Albino Rats on Oral Administration of Sodium Benzoate
نویسندگان
چکیده
The present study evaluates the histological effects of oral sodium benzoate on liver of albino rats. The study comprises of 4 groups of albino rats. Each group consists of 10 albino rats. Of these, first group was given 400mg/kg body weight sodium benzoate orally in distilled water, second group was given 800mg/kg body weight sodium benzoate in distilled water, and the third group was given 1200mg/kg body weight sodium benzoate in distilled water and the fourth group served as a control which received distilled water only. All rats were sacrificed at the end of 30 days. The changes which occurred in rats as compared to control were swelling (vacuolization), disorganization of hepatocytes, dilated central vein, hemorrhage, and syncytium formation. These alterations became more pronounced in liver of rats administered higher doses of sodium benzoate.
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